tTMB-P3(12.41) Reference Standard

CBP80001-3

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I. Background

Tumor mutational burden (TMB) shows great promise as a biomarker for immuno-oncology (I-O) therapy response, but progress is hindered by the lack of a standardized TMB measurement by targeted NGS panels, and an absence of TMB reference materials.

Sample ID	Cat.No.	Background	Assay	Comments
DC198N0161	CBP80001-3N	B lymphoblast, Female	500x WES	Same individual
DC198N0160	CBP80001-3T	Ductal breast carcinoma, Female	500x WES	Same individual
IDT xGenExome Research Panel v1.0捕獲，Target Region 39M, Probe Region 51M，CDS Region 33.52M; HiSeq X-TEN，af選擇0.02 cut off，再過濾。 DC198N0160 is 100% Tumor sample.

	Cut off =2%	Cut off =3%	Cut off =4%	Cut off =5%
Mutation Number	416	398	386	383
TMB value	12.41	11.87	11.52	11.43

計(jì)算數(shù)據(jù)下載：DC198N0160.tmb

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tTMB-P3(12.41) Reference Standard